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Cardiology in the Young

Table of Contents - 2007 - Volume 17, Issue 02  


Brief Report

Cardiac features of a novel autosomal recessive dilated cardiomyopathic syndrome due to defective importation of mitochondrial protein

Rebecca Sparkes a1, David Patton a2 and Francois Bernier a1c1
a1 Department of Medical Genetics, University of Calgary, Alberta, Canada
a2 Division of Cardiology, Department of Pediatrics, University of Calgary, Alberta, Canada

Article author query
sparkes r   [PubMed][Google Scholar] 
patton d   [PubMed][Google Scholar] 
bernier f   [PubMed][Google Scholar] 

Abstract

Dilated cardiomyopathy as seen in children is clinically and genetically heterogeneous, with an increasing proportion of cases known to be caused by disorders of single genes. An autosomal recessive syndrome with a high incidence of dilated cardiomyopathy was recently described in the Canadian Dariusleut Hutterite population. It is caused by homozygous mutations in a novel gene, DNAJC19, presumed to play a role in importation of mitochondrial proteins. We discuss the cardiac features of this syndrome, and its relationship to cardiac mitochondrial function.

(Accepted June 23 2006)


Key Words: Dilated cardiomyopathy; genetics; mitochondrial disorders.

Correspondence:
c1 Correspondence to: Dr. Francois Bernier, Department of Medical Genetics, Alberta Children's Hospital, 2888 Shaganappi Trail N.W., Calgary, Alberta T38 6A8, Canada. Tel: +403 955 7373; Fax: +403 955 2701; E-mail: francois.bernier@calgaryhealthregion.ca

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