Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus

Epidemiology and Infection

Epidemiology and Infection / Volume 139 / Special Issue 10 / October 2011, pp 1570-1579
Copyright © Cambridge University Press 2011
DOI: http://dx.doi.org/10.1017/S0950268811000550 (About DOI), Published online: 28 April 2011
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Table of Contents - October 2011 - Volume 139, Special Issue 10 (ZOONOSES)

Nipah and other viruses

Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus

Article author query
sohayati ar [PubMed] [Google Scholar]
hassan l [PubMed] [Google Scholar]
sharifah sh [PubMed] [Google Scholar]
lazarus k [PubMed] [Google Scholar]
zaini cm [PubMed] [Google Scholar]
epstein jh [PubMed] [Google Scholar]
shamsyul naim n [PubMed] [Google Scholar]
field he [PubMed] [Google Scholar]
arshad ss [PubMed] [Google Scholar]
abdul aziz j [PubMed] [Google Scholar]
daszak p [PubMed] [Google Scholar]

A. R. SOHAYATI^a1 ^c2, L. HASSAN^a2 ^c1, S. H. SHARIFAH^a3, K. LAZARUS^a4, C. M. ZAINI^a1, J. H. EPSTEIN^a5, N. SHAMSYUL NAIM^a1, H. E. FIELD^a6, S. S. ARSHAD^a2, J. ABDUL AZIZ^a7, P. DASZAK^a5 and EcoHealth Alliance^a5†

^a1Veterinary Research Institute, Department of Veterinary Services, Ipoh Perak Malaysia

^a2Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang Selangor Malaysia

^a3School of Medicine and Health Sciences, Monash University Sunway Campus, Malaysia

^a4Zoo Taiping and Night Safari , Taiping, Perak, Malaysia

^a5EcoHealth Alliance, New York, USA

^a6Biosecurity Queensland, Department of Employment, Economic Development & Innovation, QLD Australia

^a7Department of Veterinary Services, Putrajaya, Malaysia

SUMMARY

This study aimed to describe the transmission dynamics, the serological and virus excretion patterns of Nipah virus (NiV) in Pteropus vampyrus bats. Bats in captivity were sampled every 7–21 days over a 1-year period. The data revealed five NiV serological patterns categorized as high and low positives, waning, decreasing and increasing, and negative in these individuals. The findings strongly suggest that NiV circulates in wild bat populations and that antibody could be maintained for long periods. The study also found that pup and juvenile bats from seropositive dams tested seropositive, indicating that maternal antibodies against NiV are transmitted passively, and in this study population may last up to 14 months. NiV was isolated from the urine of one bat, and within a few weeks, two other seronegative bats seroconverted. Based on the temporal cluster of seroconversion, we strongly believe that the NiV isolated was recrudesced and then transmitted horizontally between bats during the study period.

(Accepted March 06 2011)

(Online publication April 28 2011)

Key Words:

Correspondence:

^c1 Author for correspondence: Dr L. Hassan, Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400 Selangor, Malaysia. (Email: latiffah@vet.upm.edu.my) [L.H.]

^c2 (Email: sohayati_abdrahman@yahoo.com.my) [A.R.S.]

Footnotes

† EcoHealth Alliance (http://www.ecohealthalliance.org).

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<div style="background: #FFFFFF; margin: 0 10px 10px 0; padding: 0 10px 0 0; text-align: left; font-family: Arial, Helvetica, sans-serif; line-height: 1em;"><div style="font-size: 11px; padding: 0px 0px 10px 0px; font-weight:bold; color: #045989;">Evidence for Nipah virus recrudescence and serological patterns of captive <i>Pteropus vampyrus</i></div><div style="font-size: 11px;"><b>
					A. R. SOHAYATI,
					L. HASSAN,
					S. H. SHARIFAH,
					K. LAZARUS,
					C. M. ZAINI,
					J. H. EPSTEIN,
					N. SHAMSYUL NAIM,
					H. E. FIELD,
					S. S. ARSHAD,
					J. ABDUL AZIZ
					 and P. DASZAK (2011).	</b><br /><a href="http://journals.cambridge.org/action/displayJournal?jid=HYG">Epidemiology and Infection</a>, <a href="http://journals.cambridge.org/action/displayJournal?jid=HYG&volumeId=139&bVolume=y#loc139>
				 ">Volume 139</a>, <a href="http://journals.cambridge.org/action/displayIssue?jid=HYG&volumeId=139&issueId=10&seriesId=0">Special Issue10</a>, October 2011 pp 1570-1579<br/>
<a href="http://journals.cambridge.org/action/displayAbstract?aid=8364526">http://journals.cambridge.org/action/displayAbstract?aid=8364526</a></div></div>

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Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus

A. R. SOHAYATI, L. HASSAN, S. H. SHARIFAH, K. LAZARUS, C. M. ZAINI, J. H. EPSTEIN, N. SHAMSYUL NAIM, H. E. FIELD, S. S. ARSHAD, J. ABDUL AZIZ and P. DASZAK October 2011
Epidemiology and Infection, ,Volume139, Special Issue10, October 2011 pp 1570-1579
http://journals.cambridge.org/10.1017/S0950268811000550

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Epidemiology and Infection

Nipah and other viruses

Evidence for Nipah virus recrudescence and serological patterns of captive Pteropus vampyrus

A. R. SOHAYATIa1 c2, L. HASSANa2 c1, S. H. SHARIFAHa3, K. LAZARUSa4, C. M. ZAINIa1, J. H. EPSTEINa5, N. SHAMSYUL NAIMa1, H. E. FIELDa6, S. S. ARSHADa2, J. ABDUL AZIZa7, P. DASZAKa5 and EcoHealth Alliancea5†

A. R. SOHAYATI^a1 ^c2, L. HASSAN^a2 ^c1, S. H. SHARIFAH^a3, K. LAZARUS^a4, C. M. ZAINI^a1, J. H. EPSTEIN^a5, N. SHAMSYUL NAIM^a1, H. E. FIELD^a6, S. S. ARSHAD^a2, J. ABDUL AZIZ^a7, P. DASZAK^a5 and EcoHealth Alliance^a5†