a1 Veterinary Research Institute, Department of Veterinary Services, Ipoh Perak Malaysia
a2 Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang Selangor Malaysia
a3 School of Medicine and Health Sciences, Monash University Sunway Campus, Malaysia
a4 Zoo Taiping and Night Safari , Taiping, Perak, Malaysia
a5 EcoHealth Alliance, New York, USA
a6 Biosecurity Queensland, Department of Employment, Economic Development & Innovation, QLD Australia
a7 Department of Veterinary Services, Putrajaya, Malaysia
This study aimed to describe the transmission dynamics, the serological and virus excretion patterns of Nipah virus (NiV) in Pteropus vampyrus bats. Bats in captivity were sampled every 7–21 days over a 1-year period. The data revealed five NiV serological patterns categorized as high and low positives, waning, decreasing and increasing, and negative in these individuals. The findings strongly suggest that NiV circulates in wild bat populations and that antibody could be maintained for long periods. The study also found that pup and juvenile bats from seropositive dams tested seropositive, indicating that maternal antibodies against NiV are transmitted passively, and in this study population may last up to 14 months. NiV was isolated from the urine of one bat, and within a few weeks, two other seronegative bats seroconverted. Based on the temporal cluster of seroconversion, we strongly believe that the NiV isolated was recrudesced and then transmitted horizontally between bats during the study period.
(Accepted March 06 2011)
(Online publication April 28 2011)
c1 Author for correspondence: Dr L. Hassan, Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400 Selangor, Malaysia. (Email: email@example.com) [L.H.]
† EcoHealth Alliance (http://www.ecohealthalliance.org).