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  • Expression of tenascin in bile duct cancer of hamster liver by combined treatment of dimethylnitrosamine with Opisthorchis viverrini infections

Journal of Helminthology

Table of Contents - 2002 - Volume 76, Issue 03  

Cambridge Journals Online - CUP Full-Text Page

Review Article

Expression of tenascin in bile duct cancer of hamster liver by combined treatment of dimethylnitrosamine with Opisthorchis viverrini infections

P. Sithithaworna1 c1, K. Andoa2 c1, W. Limviroja2, S. Tesanaa1, C. Pairojkula3, W. Yutanawiboonchaia3, Y. Chinzeia2, T. Yoshidaa4 and T. Sakakuraa4



a1 Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

a2 Department of Medical Zoology, School of Medicine, Mie University, Tsu 514-0001, Japan.

a3 Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

a4 Department of Pathology, School of Medicine, Mie University, Tsu 514-0001, Japan.

Article author query

Sithithaworn P [PubMed]  [Google Scholar]
Ando K [PubMed]  [Google Scholar]
Limviroj W [PubMed]  [Google Scholar]
Tesana S [PubMed]  [Google Scholar]
Pairojkul C [PubMed]  [Google Scholar]
Yutanawiboonchai W [PubMed]  [Google Scholar]
Chinzei Y [PubMed]  [Google Scholar]
Yoshida T [PubMed]  [Google Scholar]
Sakakura T [PubMed]  [Google Scholar]

Abstract

Tenascin is an extracellular matrix glycoprotein known to be an essential factor for the modulation of reciprocal interactions between the epithelium and mesenchyme during embryogenesis and tumourigenesis. The interactions between the expression of tenascin in the liver of Syrian golden hamster and the development of bile duct cancer in an Opisthorchis viverrini-associated cholangiocarcinoma model were investigated. The tenascin was expressed in connective tissues surrounding the dilated ducts, ductal rims and the stroma of cancers, and strongly in the stroma flame of necrotic cancer nodules. The mRNA signal for tenascin was also recognized in the stroma cells. The potential roles of tenascin as prognostic tumour markers are discussed.

(Accepted June 05 2002)

Correspondence:

c1 Author for correspondence Fax: + 81 59 231 5215 E-mail: ando@doc.medic.mie-u.ac.jp