5-HT1B receptor knockout mice: a review
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in a number of physiological functions including sleep, appetite, pain perception, and sexual activity. Several pathological states such as migraine, depression, and anxiety have been linked to the serotonergic system, and serotonergic drugs have been used to treat these disorders. To date, there are 14 known serotonin receptor subtypes through which serotonin exerts its multiple actions. The classic pharmacological approach to study how these individual receptor subtypes contribute to various behaviours has been to use selective drugs that either block or activate certain receptor subtypes, and then study the effects of these compounds on physiology and behaviour. A complementary genetic approach is the technique of gene targeting. Using this technology, we and others have begun to examine the contribution of several serotonin receptor subtypes to complex behaviours through the generation of knockout mice that lack the genes encoding these receptors. In this review, we will describe what we have learned about the serotonergic system and the function of the 5-HT1B receptor by the analysis of 5-HT1B receptor knockout mice. Furthermore, we will discuss the implications of these findings and our plans for future studies.(Received December 9 1998)
( Reviewed 22 February, 1999; February 22 1999)
(Revised March 21 1999)
(Accepted March 22 1999)
Key Words: Serotonin; knockout; animal model; genetic disease; psychiatric disorder.
c1 Address for correspondence: Dr René Hen, Columbia University, Center for Neurobiology and Behavior, 722 West 168th Street, New York, New York 10032. Tel.: (212) 543-5328 Fax: (212) 543-5410. E-mail: email@example.com