Psychological Medicine
- Psychological Medicine / Volume 9 / Issue 02 / May 1979, pp 249-263
- Copyright © Cambridge University Press 1979
- DOI: http://dx.doi.org/10.1017/S0033291700030749 (About DOI), Published online: 09 July 2009
Research Article
Physiological and pharmacological basis for the chemotherapy of enuresis1
J. D. Stephensona1 c1
a1 Department of Pharmacology, Institute of Psychiatry, London
Abstract
Enuresis is a disorder of micturition occurring in the absence of an organic urinary tract lesion. To understand its possible causation, the mechanisms controlling micturition are described together with the possible sites of action of various anti-enuretic agents, particularly imipramine. It is concluded that further research into the central control of micturition is required before the precise actions of centrally-acting anti-enuretic agents can be elucidated. Knowledge of these may give insight into the nature of the defect causing enuresis.
Correspondence:
c1 Address for correspondence: Dr J. D. Stephenson, Department of Pharmacology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
Footnotes
1 This article formed the basis of a lecture given at the Institute of Psychiatry, London, October 1977.
