a1 Common Cold Research Unit of the Medical Research Council, Salisbury, Wilts
Eighteen volunteers were given live adenovirus attenuated by passage in pig kidney tissue culture. Thirteen were given adenovirus Type 7 and five were given adenovirus Type 4. All volunteers who were given Type 7 and who had no homologous neutralizing antibody on inoculation showed antibody rises. Except in one volunteer not in isolation no signficant symptoms were seen.
It is suggested that adenoviruses attenuated in this way might be useful for large-scale vaccination programmes.
(Received March 23 1960)