Journal of Hygiene

Table of Contents - 1960 - Volume 58, Issue 03  

Research Article

Vaccination of man with attentuated live adenovirus

Griselda Hitchocka1, D. A. J. Tyrrella1 and M. L. Bynoea1

a1 Common Cold Research Unit of the Medical Research Council, Salisbury, Wilts

Eighteen volunteers were given live adenovirus attenuated by passage in pig kidney tissue culture. Thirteen were given adenovirus Type 7 and five were given adenovirus Type 4. All volunteers who were given Type 7 and who had no homologous neutralizing antibody on inoculation showed antibody rises. Except in one volunteer not in isolation no signficant symptoms were seen.

It is suggested that adenoviruses attenuated in this way might be useful for large-scale vaccination programmes.

(Received March 23 1960)

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