Cambridge Quarterly of Healthcare Ethics



SPECIAL SECTION: ETHICAL LIMITS IN HUMAN SUBJECTS RESEARCH

The Poster Child for the Need for Central Review of Research Protocols: The Children's Oncology Group


REBECCA D.  PENTZ  a1 and ANITA F.  KHAYAT  a2
a1 Rebecca D. Pentz, Ph.D., is Associate Professor of Hematology and Oncology in Research Ethics at the Winship Cancer Institute of Emory University, Atlanta, Georgia
a2 Anita F. Khayat, Ph.D., M.B.A., is Executive Officer at the Children's Oncology Group in Arcadia, California

Article author query
pentz rd   [PubMed][Google Scholar] 
khayat af   [PubMed][Google Scholar] 

Multiple groups, including the National Bioethics Advisory Commission, the American Society of Clinical Oncology (ASCO), the National Coalition of Comprehensive Cancer Centers (Personal communication with Robert B. Catalano, PharmD, Vice President for Regulatory Affairs, Coalition of National Cancer Cooperative Groups), Workgroup 6 of the Summit Series on Cancer, PRIM&R, the Bell Report, and prominent ethicists have called for replacing the current system of local institutional review with central review for multisite national trials. We argue that this need is particularly acute in pediatric oncology, as shown by the experience of the Children's Oncology Group (COG).



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